This post by security expert Peter Gutmann is frightening in its assessment of the impact and underlying philosophy of Microsoft Vista.
Consider a medical IT worker who's using a medical imaging PC while listening to audio/video played back by the computer (the CDROM drives installed in workplace PCs inevitably spend most of their working lives playing music or MP3 CDs to drown out workplace noise). If there's any premium content present in there, the image will be subtly altered by Vista's content protection,
potentially creating exactly the life-threatening situation that the medical
industry has worked so hard to avoid.
The type and degree of lock-in described in the article is utterly frightening, harkening back to the Ma Bell days.